abstract：:It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown ...

journal_title：EBioMedicine

authors： Jin Y,Wang J,Li H,Gao S,Shi R,Yang D,Wang X,Wang X,Zhu L,Wang X,Chen C,Ning K,Gao Z,Xu J,Fu Q

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The contribution of hepcidin as a regulator of iron metabolism & erythropoiesis on the severity of anemia in sickle cell disease (SCD) remains poorly characterized, especially in Sub-Saharan African populations. The aims of the study were to determine if hepcidin is associated with severity of steady-state a...

journal_title：EBioMedicine

authors： Lee N,Makani J,Tluway F,Makubi A,Armitage AE,Pasricha SR,Drakesmith H,Prentice AM,Cox SE

更新日期：2018-08-01 00:00:00

abstract：:Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a compr...

journal_title：EBioMedicine

authors： Zhu J,Jia W,Wu C,Fu W,Xia H,Liu G,He J

更新日期：2018-07-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological processes. HDAC11, the last identified and sole member of class IV HDACs, w...

journal_title：EBioMedicine

authors： Sun L,Marin de Evsikova C,Bian K,Achille A,Telles E,Pei H,Seto E

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Human infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated with a high mortality rate. However, the metabolic basis of such systemic alterations remains unknown. METHODS:This study included hospitalized patients (n = 4) with laboratory-confirm...

journal_title：EBioMedicine

authors： Sun X,Song L,Feng S,Li L,Yu H,Wang Q,Wang X,Hou Z,Li X,Li Y,Zhang Q,Li K,Cui C,Wu J,Qin Z,Wu Q,Chen H

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Dupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures of the fingers, with no approved therapy for early stage disease. Our previous analysis of surgically-excised tissue defined tumour necrosis factor (TNF) as a potential therapeutic target. Here we ass...

journal_title：EBioMedicine

authors： Nanchahal J,Ball C,Davidson D,Williams L,Sones W,McCann FE,Cabrita M,Swettenham J,Cahoon NJ,Copsey B,Anne Francis E,Taylor PC,Black J,Barber VS,Dutton S,Feldmann M,Lamb SE

更新日期：2018-07-01 00:00:00

abstract：:Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known about its cellular basis or what defines the transition from physiolog...

journal_title：EBioMedicine

authors： Lin JB,Sene A,Santeford A,Fujiwara H,Sidhu R,Ligon MM,Shankar VA,Ban N,Mysorekar IU,Ory DS,Apte RS

更新日期：2018-06-01 00:00:00

abstract：:Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission of ATP. FLX increased ATP ...

journal_title：EBioMedicine

authors： Kinoshita M,Hirayama Y,Fujishita K,Shibata K,Shinozaki Y,Shigetomi E,Takeda A,Le HPN,Hayashi H,Hiasa M,Moriyama Y,Ikenaka K,Tanaka KF,Koizumi S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS:Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagn...

journal_title：EBioMedicine

authors： Wu S,Chen JN,Zhang QW,Tang CT,Zhang XT,Tang MY,Li XB,Ge ZZ

更新日期：2018-06-01 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed cancer in males in the Western world. Although prostate-specific antigen (PSA) has been widely used as a biomarker for PCa diagnosis, its results can be controversial. Therefore, new biomarkers are needed to enhance the clinical management of PCa. From publicly avai...

journal_title：EBioMedicine

authors： Hou Q,Bing ZT,Hu C,Li MY,Yang KH,Mo Z,Xie XW,Liao JL,Lu Y,Horie S,Lou MW

更新日期：2018-06-01 00:00:00

abstract：:Cerebral microinfarcts have significant effects on the development of geriatric neurological disorders, including vascular dementia and Alzheimer's disease. However, little is known about the pathophysiological mechanisms involved in the evolution of microinfarcts and potential treatment and prevention against these m...

journal_title：EBioMedicine

authors： Luo C,Ren H,Yao X,Shi Z,Liang F,Kang JX,Wan JB,Pei Z,Su KP,Su H

更新日期：2018-06-01 00:00:00

abstract：:Previous transcriptomic analyses suggested that the 1918 influenza A virus (IAV1918), one of the most devastating pandemic viruses of the 20th century, induces a dysfunctional cytokine storm and affects other innate immune response patterns. Because all viruses are obligate parasites that require host cells for replic...

journal_title：EBioMedicine

authors： Ranadheera C,Coombs KM,Kobasa D

更新日期：2018-06-01 00:00:00

abstract：:Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associat...

journal_title：EBioMedicine

authors： Danielson KM,Shah R,Yeri A,Liu X,Camacho Garcia F,Silverman M,Tanriverdi K,Das A,Xiao C,Jerosch-Herold M,Heydari B,Abbasi S,Van Keuren-Jensen K,Freedman JE,Wang YE,Rosenzweig A,Kwong RY,Das S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeat...

journal_title：EBioMedicine

authors： Lee JK,Conrad A,Epping E,Mathews K,Magnotta V,Dawson JD,Nopoulos P

更新日期：2018-05-01 00:00:00

abstract：:G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid. Here, we assessed the anti-inflammatory activity of sodium butyrate (SB) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, an experimenta...

journal_title：EBioMedicine

authors： Chen G,Ran X,Li B,Li Y,He D,Huang B,Fu S,Liu J,Wang W

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Visual function and brain function decline concurrently with aging. Notably, cataract patients often present with accelerated age-related decreases in brain function, but the underlying mechanisms are still unclear. Optical structures of the anterior segment of the eyes, such as the lens and cornea, can be r...

journal_title：EBioMedicine

authors： Lin H,Zhang L,Lin D,Chen W,Zhu Y,Chen C,Chan KC,Liu Y,Chen W

更新日期：2018-04-01 00:00:00

abstract：:Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, V...

journal_title：EBioMedicine

authors： Gargan S,Ahmed S,Mahony R,Bannan C,Napoletano S,O'Farrelly C,Borrow P,Bergin C,Stevenson NJ

更新日期：2018-04-01 00:00:00

abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

journal_title：EBioMedicine

authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:T-cell responses against highly conserved influenza antigens have been previously associated with protection. However, these immune responses are poorly maintained following recovery from influenza infection and are not boosted by inactivated influenza vaccines. We have previously demonstrated the safety and...

journal_title：EBioMedicine

authors： Coughlan L,Sridhar S,Payne R,Edmans M,Milicic A,Venkatraman N,Lugonja B,Clifton L,Qi C,Folegatti PM,Lawrie AM,Roberts R,de Graaf H,Sukhtankar P,Faust SN,Lewis DJM,Lambe T,Hill A,Gilbert SC

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation succes...

journal_title：EBioMedicine

authors： Diaz Heijtz R,Almeida R,Eliasson AC,Forssberg H

更新日期：2018-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated protein kinase (AMPK) is viewed as a pathogenic factor in the development of fatty liver its role has not been directly demonstrated. Une...

journal_title：EBioMedicine

authors： Boudaba N,Marion A,Huet C,Pierre R,Viollet B,Foretz M

更新日期：2018-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent a mechanistic link between Aβ/tau deposition after TBI and the development of post conc...

journal_title：EBioMedicine

authors： Ramos-Cejudo J,Wisniewski T,Marmar C,Zetterberg H,Blennow K,de Leon MJ,Fossati S

更新日期：2018-02-01 00:00:00

abstract：:Angiogenesis is the formation of new capillaries from pre-existing blood vessels and participates in proper vasculature development. In pathological conditions such as cancer, abnormal angiogenesis takes place. Angiogenesis is primarily carried out by endothelial cells, the innermost layer of blood vessels. The vascul...

journal_title：EBioMedicine

authors： Pauty J,Usuba R,Cheng IG,Hespel L,Takahashi H,Kato K,Kobayashi M,Nakajima H,Lee E,Yger F,Soncin F,Matsunaga YT

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

journal_title：EBioMedicine

authors： Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS:Clozapine and norclozapine ste...

journal_title：EBioMedicine

authors： Menkes DB,Glue P,Gale C,Lam F,Hung CT,Hung N

更新日期：2018-01-01 00:00:00

abstract：:A small subset of HIV-1 infected individuals, the "Elite Controllers" (EC), can control viral replication and restrain progression to immunodeficiency without antiretroviral therapy (ART). In this study, a cross-sectional transcriptomics and targeted proteomics analysis were performed in a well-defined Swedish cohort ...

journal_title：EBioMedicine

authors： Zhang W,Ambikan AT,Sperk M,van Domselaar R,Nowak P,Noyan K,Russom A,Sönnerborg A,Neogi U

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

journal_title：EBioMedicine

authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

更新日期：2017-12-01 00:00:00

abstract：:In 2009 the U.S. Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD). In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly available bioactivity and drug safe...

journal_title：EBioMedicine

authors： Xu D,Ham AG,Tivis RD,Caylor ML,Tao A,Flynn ST,Economen PJ,Dang HK,Johnson RW,Culbertson VL

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunologica...

journal_title：EBioMedicine

authors： Bremer L,Goletzke J,Wiessner C,Pagenkemper M,Gehbauer C,Becher H,Tolosa E,Hecher K,Arck PC,Diemert A,Tiegs G

更新日期：2017-12-01 00:00:00

abstract：:Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fr...

journal_title：EBioMedicine

authors： Chen X,Su T,Chen Y,He Y,Liu Y,Xu Y,Wei Y,Li J,He R

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:A phase II study of methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) sandwiched with radiotherapy for newly diagnosed, stage IE-IIE extranodal natural-killer/T-cell lymphoma, nasal-type (ENKTL) was conducted to explore its clinical efficacy and safety, as well as novel serum biomarkers upon an...

journal_title：EBioMedicine

authors： Xu PP,Xiong J,Cheng S,Zhao X,Wang CF,Cai G,Zhong HJ,Huang HY,Chen JY,Zhao WL

更新日期：2017-11-01 00:00:00

abstract：:A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially decreases Aβ42 levels. H...

journal_title：EBioMedicine

authors： Raven F,Ward JF,Zoltowska KM,Wan Y,Bylykbashi E,Miller SJ,Shen X,Choi SH,Rynearson KD,Berezovska O,Wagner SL,Tanzi RE,Zhang C

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

journal_title：EBioMedicine

authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

更新日期：2017-10-01 00:00:00

abstract：:Therapeutic approaches to fight Alzheimer's disease include anti-Amyloidβ (Aβ) antibodies and secretase inhibitors. However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB permeable. The Brain Shuttle (BS) technology is capable of shuttling lar...

journal_title：EBioMedicine

authors： Ruderisch N,Schlatter D,Kuglstatter A,Guba W,Huber S,Cusulin C,Benz J,Rufer AC,Hoernschemeyer J,Schweitzer C,Bülau T,Gärtner A,Hoffmann E,Niewoehner J,Patsch C,Baumann K,Loetscher H,Kitas E,Freskgård PO

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt signaling, in patients with HCV cirrhosis. METHODS:In this single-center...

journal_title：EBioMedicine

authors： Kimura K,Ikoma A,Shibakawa M,Shimoda S,Harada K,Saio M,Imamura J,Osawa Y,Kimura M,Nishikawa K,Okusaka T,Morita S,Inoue K,Kanto T,Todaka K,Nakanishi Y,Kohara M,Mizokami M

更新日期：2017-09-01 00:00:00

abstract：:The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent protein kinase-1 (PDPK1) signaling to ensure the completion of its developmental...

journal_title：EBioMedicine

authors： Al-Zeer MA,Xavier A,Abu Lubad M,Sigulla J,Kessler M,Hurwitz R,Meyer TF

更新日期：2017-09-01 00:00:00

abstract：:Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the latent HIV reservoir, defined as the triggering of viral antigen producti...

journal_title：EBioMedicine

authors： Sung JA,Sholtis K,Kirchherr J,Kuruc JD,Gay CL,Nordstrom JL,Bollard CM,Archin NM,Margolis DM

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:The phase III clinical trial PERFECT was designed to assess clinical safety and efficacy of intramyocardial CD133+ bone marrow stem cell treatment combined with CABG for induction of cardiac repair. DESIGN:Multicentre, double-blinded, randomised placebo controlled trial. SETTING:The study was conducted acro...

journal_title：EBioMedicine

authors： Steinhoff G,Nesteruk J,Wolfien M,Kundt G,PERFECT Trial Investigators Group.,Börgermann J,David R,Garbade J,Große J,Haverich A,Hennig H,Kaminski A,Lotz J,Mohr FW,Müller P,Oostendorp R,Ruch U,Sarikouch S,Skorska A,Sta

更新日期：2017-08-01 00:00:00

abstract：:Intestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins in blood and intestinal secretions. ...

journal_title：EBioMedicine

authors： Amadi B,Besa E,Zyambo K,Kaonga P,Louis-Auguste J,Chandwe K,Tarr PI,Denno DM,Nataro JP,Faubion W,Sailer A,Yeruva S,Brantner T,Murray J,Prendergast AJ,Turner JR,Kelly P

更新日期：2017-08-01 00:00:00

abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

journal_title：EBioMedicine

authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

更新日期：2017-07-01 00:00:00